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CD50 (CDw50, Intercellular Adhesion Molecule 3, ICAM 3, ICAM3, ICAM-3, ICAM-R) (Azide Free)

CD50 (CDw50, Intercellular Adhesion Molecule 3, ICAM 3, ICAM3, ICAM-3, ICAM-R) (Azide Free)

Cat no: C2405-07A

Supplier: United States Biological
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CD5 is also known as Inter-cellular adhesion molecule-3 (ICAM-3). CD50 is an 110kD type I transmembrane glycoprotein which is expressed mainly on resting leukocytes. It interacts with lymphocyte function-associated antigen-1 (LFA-1) and DC-SIGN, and is involved in the intercellular adhesion of leukocytes and augments CD3 signalling in T-lymphocyte activation. CD50 expression induces cancer cell proliferation and over-expression may contribute to cancer progression. It has also been implicated in limiting HIV-1 replication. Applications: Suitable for use in Flow Cytometry and Immunoprecipitation. Other applications not tested. Recommended Dilution: Flow Cytometry: Neat-1:200; 10ul labels 10e6 cells in 100ul Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2405-07A
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunoprecipitation
Size: 200ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography.
References: 1. Biggins, J.E. et al. (2007) ICAM-3 influences human immunodeficiency virus type 1 replication in CD4(+) T cells independent of DC-SIGN-mediated transmission. Virology. 364: 383-394.2. Berney, S.M. et al. (1999) ICAM-3 (CD50) cross-linking augments signaling in CD3-activated peripheral human T lymphocytes. J. Leukoc. Biol. 65: 867-874.3. Kim, Y.G. et al. (2006) ICAM-3-induced cancer cell proliferation through the PI3K/Akt pathway. Cancer Lett. 239: 103-110.4. Garland Publishing, Inc. (1998) . Leucocyte Typing VI. 403
Additional info: Recognizes human CD50.

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