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CD51 (CD51 Antigen, Integrin alpha V, ITGAV, Msk8, Vitronectin Receptor alpha Polypeptide, Vitronectin Receptor Subunit alpha, VNRA)

CD51 (CD51 Antigen, Integrin alpha V, ITGAV, Msk8, Vitronectin Receptor alpha Polypeptide, Vitronectin Receptor Subunit alpha, VNRA)

Cat no: C2405-11P2

Supplier: United States Biological
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CD51, a 140 kD alpha subunit of the vitronectin receptor, which is otherwise known as the integrin alpha v chain. CD51 can form heterodimers at the cell surface with a variety of beta integrins including CD29 and CD61. Heterodimers of CD51/CD61 function as a receptor for vitronectin, and a wide array of RGD-containing proteins including fibronectin, fibrinogen, von Willebrand factor, laminin, thrombospondin and osteopontin. CD51/CD61 is primarily expressed on myeloid cells and activated T-cells. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing. Applications: Suitable for use in Flow Cytometry and Immunoprecipitation. Other applications not tested. Recommended Dilution: Flow Cytometry: 1:10-1:100; 10ul labels 10e6 cells in 100ul Optimal dilutions to be determined by the researcher. Hybridoma: P3X.63Ag8.653 myeloma cells with spleen cells from SD rats. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2405-11P2
Reactivities: Mouse
Hosts: Rat
Applications: Flow Cytometry, Immunoprecipitation
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography.
References: 1. Takahashi K. et al. (1990) A murine very late activation antigen-like extracellular matrix receptor involved in CD2- and lymphocyte function-associated antigen-1-independent killer-target cell interaction. J. Immunol.145: 4371
Additional info: Recognizes mouse CD51. Reported to block binding of CD51 to vitronectin, fibronectin, and CD31 in some cell types, as well as blocking LAK cell cytotoxicity (1).

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