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CD51 (Integrin alpha-V, Vitronectin Receptor Subunit alpham ITGAV, MSK8, VNRA)

CD51 (Integrin alpha-V, Vitronectin Receptor Subunit alpham ITGAV, MSK8, VNRA)

Cat no: C2405-11R

Supplier: United States Biological
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CD51 is a type I integral membrane glycoprotein, known as vitronectin receptor a chain, or integrin aV. It forms heterodimer with integrin b1 (CD29), b3 (CD61), b5, b6, or b8. CD51 contains two disulfide-linked subunits of 125 kD and 24 kD, and is expressed on endothelial cells, fibroblasts, macrophages, platelets, osteoclasts, neuroblastoma, melanoma, and hepatoma cells. Many extracellular matrix proteins with RGD-motifs are CD51 ligands. In association with its b chains, CD51 binds vitronectin, von Willebrand factor, fibronectin, thrombospondin, osteopontin, fibrinogen, and laminin. CD51, as an adhesion molecule, plays important roles in leukocytes homing and rolling, mediates bone absorption and angiogenesis. Applications: Suitable for use in Flow Cytometry, Immunoprecipitation and ELISA. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2405-11R
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Flow Cytometry, Immunoprecipitation
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG2a,k
Purity: Purified by immunoaffinity chromatography.
References: 1. Knapp, W., et al. Eds. 1989. Leucocyte Typing IV. Oxford University Press. New York. 2. Defilippi, P., et al. 1991. J. Cell Biol. 114:855. 3. Burdick, MM., et al. 2003. Am. J. Physiol.-Cell Ph. 284:C977. 4. Grzeszkiewicz, TM., et al. 2001. J. Biol. Chem. 276:21943. 5. Sonnenberg, A., et al. 1990. J. Cell Biol. 110:2145. 6. Nesbitt, S., et al. 1993. J. Biol. Chem. 268:16737. 7. Zola, H., et al. 2007. Leukocyte and Stromal Cell Molecules: The CD Markers Wiley-Liss A John Wiley & Sons, Inc., Publication
Additional info: Recognizes human CD51.

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