CD52 (HI186) Antibody

Cat no: 250971

Supplier: ABBIOTEC

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Description
Additional Information

The CD52 (HI186) antibody recognizes a 25-29 kDa glycosylphosphatidylinositol (GPI)-anchored single chain glycoprotein typically e, Xenopus/Amphibian,pressed at high levels on thymocytes, lymphocytes, NK cells,Mouse,onocytes/macrophages. CD52 is e, Xenopus/Amphibian,pressed at 2% on some granulocytes and epithelial cells of male reproductive tract, and also e, Xenopus/Amphibian,pressed at variable levels on the majority of lymphoid malignancies, but not on erythrocytes and platelets. A somatic defect in the synthesis of GPI anchors causes a lack of CD52 antigen on cell surface on lymphocytes from patients with paro, Xenopus/Amphibian,ysmal nocturnal haemoglobinuria (PNH) . CD52 may be used to diagnose PNH besides CD55 and CD59. All CD52 antibodies are characterized by a strong lytic activity with human complement, irrespective of antibody isotype.

Catalogue number:	250971
Reactivities:	Human
Applications:	Flow Cytometry, Immunohistochemistry
Size:	0.1 mg
Accession:	P31358
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Mouse Monoclonal Antibody
Isotype:	mouse IgG2b
Clonality:	HI186
Additional info:	CD52; CAMPATH-1 antigen; Cambridge pathology 1 antigen; Epididymal secretory protein E5; CDw52