Home  >  Products  >  CD54 (BB2, Cell Surface Glycoprotein P3.58, Human Rhinovirus Receptor, Intercellular Adhesion Molecule 1, ICAM 1, ICAM-1, Major Group Rhinovirus Receptor, MALA-2, MyD10, P3.58) (Biotin)
CD54 (BB2, Cell Surface Glycoprotein P3.58, Human Rhinovirus Receptor, Intercellular Adhesion Molecule 1, ICAM 1, ICAM-1, Major Group Rhinovirus Receptor, MALA-2, MyD10, P3.58) (Biotin)

CD54 (BB2, Cell Surface Glycoprotein P3.58, Human Rhinovirus Receptor, Intercellular Adhesion Molecule 1, ICAM 1, ICAM-1, Major Group Rhinovirus Receptor, MALA-2, MyD10, P3.58) (Biotin)

Cat no: C2409-11C3

Supplier: United States Biological
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CD54 cell surface antigen, also known as intercellular adhesion molecule-1 (ICAM-1), is a 90kD adhesion molecule belonging to the immunoglobulin superfamily. The rat ICAM-1 molecule has an important role in various cell-cell interactions in the immune system. IP analysis shows that the antigen has the same features as human ICAM-1. In addition, recent studies suggest that cross-linking of ICAM-1 induces calcium signalling. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry: Neat-1:5; 10ul labels 10e6 cells in 100ul Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2409-11C3
Reactivities: Rat
Hosts: Mouse
Applications: Flow Cytometry
Conjugates: Biotin
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.4, 1% BSA, 0.09% sodium azide. Labeled with Biotin.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography.
References: 1. Tamatani, T and Miyasaka, M. (1990) Identification of monoclonal antibodies reactive with the rat homolog of ICAM-1, and evidence for a differential involvement of ICAM-1 in the adherence of resting versus activated lymphocytes to high endothelial cells. Int. Immunol. 2: 165-171, 2. Tamatani, T. et al. (1991) Molecular mechanisms underlying lymphocyte recirculation. II. Differential regulation of LFA-1 in interaction between lymphocytes and high endothelial cells. Eur. J. Immunol. 21: 855-858, 3. Etienne, S. et al. (1998) ICAM-1 signalling pathways associated with Rho activation in microvascular brain endothelial cells. J. Immunol. 161: 5755-5761, 4. Etienne, S. et al. (2000) ICAM-1-coupled cytoskeletal rearrangements and transendothelial lymphocyte migration involve intracellular calcium signaling in brain endothelial cell lines. J. Immunol. 165: 3375-3383, 5. McKechnie, N. M. et al. (2002) Antigenic mimicry: Onchocerca volvulus antigen-specific T cells and ocular inflammation. Invest Ophthalmol Vis Sci. 43:411-8.
Additional info: Recognizes rat CD54.

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