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CD54 (Intercellular Adhesion Molecule 1, ICAM-1, Major Group Rhinovirus Receptor, ICAM1)

CD54 (Intercellular Adhesion Molecule 1, ICAM-1, Major Group Rhinovirus Receptor, ICAM1)

Cat no: C2409-46G

Supplier: United States Biological
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CD54, a 75-114kD inducible surface glycoprotein, is a novel member of Ig superfamily consisting of 5 Ig-like domains in the extracellular region, a transmembrane region and a short cytoplasmic tail. It is expressed on endothelial cells, leukocytes, Lymphocytes, and Monocytes and is used as a functional receptor for Major group of Human Rhinovirus. It binds to CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1) and promotes the adhesion and transendothelial migration of leukocytes during inflammatory responses. Its other functions include Cell-Cell adhesion during immune responses, activating signaling pathways in endothelial cells and functioning as a co-stimulatory molecule for T-cell activation in APCs. Its expression can be up-regulated by various stress stimuli and inflammatory cytokines and involves NF-kB dependent and independent signaling pathways. Applications: Suitable for use in Flow Cytometry, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:100-1:500 Immunohistochemistry (paraffin): 1:75-1:150 Immunohistochemistry: Frozen Optimal dilutions to be determined by the researcher. Positive Control: Human T cell line Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2409-46G
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry, Western Blot
Size: 500ul
Form: Supplied as a liquid, 0.05% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified
References: 1. Albelda et al. FASEB J 4: 2868, 1990. 2. Garioch et al. Histopathol 19: 351, 1991. 3. Hynes et al. Cell 48: 549, 1987. 4. Takeichi et al. Science 251: 1451, 1991. 5. Greve et.al Cell 56 (5); 839-847 (Mar 10, 1989) 6. Huang et.al J. Biol. Chem 278 (11); 9944-9952 (Mar 14, 2003) 7. Gorgoulis et.al EMBO J 22; 1567-1578 (2003).
Additional info: Recognizes human CD54.

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