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CD54, phosphorylated (Tyr512) (Intercellular Adhesion Molecule 1, ICAM-1, Major Group Rhinovirus Receptor, ICAM1)

CD54, phosphorylated (Tyr512) (Intercellular Adhesion Molecule 1, ICAM-1, Major Group Rhinovirus Receptor, ICAM1)

Cat no: C2409-46J

Supplier: United States Biological
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ICAM-1 is a novel member of Ig superfamily consisting of 5 Ig-like domains in the extracellular region, a transmembrane region and a short cytoplasmic tail. It is expressed on endothelial cells, leukocytes, lymphocytes, and monocytes and is used as a functional receptor for major group of human rhinovirus. It binds to CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1) and promotes the adhesion and transendothelial migration of leukocytes during inflammatory responses. Its other functions include cell-cell adhesion during immune responses, activating signaling pathways in endothelial cells and functioning as a co-stimulatory molecule for T-cell activation in APCs. Its expression can be up-regulated by various stress stimuli and inflammatory cytokines and involves NF-kB dependent and independent signaling pathways. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Positive Control: HUVEC cells Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2409-46J
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Huang, WC. et al. J. Biol. Chem. 278:9944-9952 (2003). 2. Gorgoulis, G. et al. EMBO. J. 22:1567-1578 (2003).
Additional info: Recognizes human ICAM-1, phosphorylated at Tyr512. Species Crossreactivity: mouse and rat.

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