In accord with its role in protecting tissues from complement mediated lysis, CD55 is broadly distributed among cells in contact with serum, including both haematopoietic and nonhaematopoietic cells. An acquired disorder, PNH which leads to bouts of haemolysis, is at least partially caused by a deficiency of CD55 and CD59 as a result of defects in GPI anchor biosynthesis.
Applications:
Suitable for use in Flow Cytometry, Western Blot and Immunoprecipitation. Other applications not tested.
Recommended Dilution:
Western Blot: Non-reducing conditions
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.