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CD55 (Complement Decay-accelerating Factor, CR, DAF)

CD55 (Complement Decay-accelerating Factor, CR, DAF)

Cat no: C2410-10F

Supplier: United States Biological
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CD55 is a 60-70 kD glycosylphosphatidylinositol (GPI)-anchored single chain glycoprotein also known as decay-accelerating factor (DAF). It is expressed on hematopoietic cells including erythrocytes and many non-hematopoietic cells. CD55 accelerates the dissociation of the components of the C3-convertases (namely C2a from C4b in the C4bC2a complex, a C3-convertase of the classical pathway, and factor Bb from the C3bBb complex, a C3-convertase of the alternative pathway) to protect cells from inappropriate damage caused by autologous complement. CD55 has been reported to reduce the efficiency of NK cell lysis and induce signal transduction in T cells. CD55 has also been shown to interact with CD97 and bind to Coxsackie and Echovirus. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2410-10F
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG1,k
Purity: Purified by immunoaffinity chromatography.
References: 1. Kishimoto, T., et al. Eds. 1997. Leucocyte Typing VI. Garland Publishing, Inc. London. 2. Peyron, P., et al. 2000. J. Immunol. 165:5186. 3. Schlossman, S., et al. Eds. 1995. Leucocyte Typing V. Oxford University Press. New York. 4. Hamann, J., et al. 1996. J. Exp. Med. 184:1185. 5. Fujita, T., et al. 1987. J. Exp. Med. 166:1221
Additional info: Recognizes human CD55.

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