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CD56 (NCAM-1, Neural Cell Adhesion Molecule)

CD56 (NCAM-1, Neural Cell Adhesion Molecule)

Cat no: C2410-56C

Supplier: United States Biological
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The neural cell adhesion molecule (NCAM/CD56) has been shown to mediate homophilic cell-cell adhesion in the neuroendocrine system with interactions among immunoglobulin-like domains. It is a multifunction transmembrane protein involved in synaptic plasticity, neurodevelopment and neurogenesis. NCAM appears on early embryonic cells and is important in the formation of cell collectives and their boundaries at sites of morphogenesis (1-3). It is preferentially expressed on human NK cells and a subset of T lymphocytes that mediate MHC-unrestricted cell-mediated cytotoxicity (1). Single nucleotide polymorphisms (SNPs) in the NCAM gene are reported to be significantly associated with bipolar disorder in the Japanese population (3). Applications: Suitable for use in Western Blot, Immunohistochemistry, Immunocytochemistry, Flow Cytometry and Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 1:1000-1:10,000 Immunohistochemistry: 1:500-1:2000 Immunocytochemistry: 1:100-1:250 Flow Cytometry: 1:150 Immunoprecipitation: 1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: C2410-56C
Reactivities: Human
Hosts: Rabbit
Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50mM Tris-Glycine, pH 7.4, 0.15M sodium chloride, 0.05% BSA, 0.01% sodium azide, 40% glycerol.
P type: Mab
Isotype: IgG
Purity: Supernatant
Alternative names: NCAM-1, N-CAM-1, CD56 antigen
References: 1. Lanier, L.L., et al., J. Immunol. 146(12): 4421-4426 (1991). 2. Cunningham, B.A., et al., Science 236(4803): 799-806 (1987). 3. Atz, M.E., et al., Psychiatr. Genet. 17(2): 55-67 (2007).
Additional info: Recognizes human CD56/NCAM at ~180kD.

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