Home  >  Products  >  CD58 (CD58 Antigen, Ag3, Lymphocyte Function Associated Antigen Type 3, LFA3, LFA-3, Surface Glycoprotein LFA-3)
CD58 (CD58 Antigen, Ag3, Lymphocyte Function Associated Antigen Type 3, LFA3, LFA-3, Surface Glycoprotein LFA-3)

CD58 (CD58 Antigen, Ag3, Lymphocyte Function Associated Antigen Type 3, LFA3, LFA-3, Surface Glycoprotein LFA-3)

Cat no: C2412-06T

Supplier: United States Biological
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CD58, or LFA-3, is a membrane glycoprotein of 55-70kD. It occurs in two forms, one transmembrane with a cytoplasmic domain, the other form anchored in the membrane via a glycosylphosphatidylinositol tail. The complete amino acid sequence of both forms has been deduced from cDNA. It is heavily N-glycosylated. CD58 is a cell adhesion molecule which plays a critical role in facilitation of antigen specific recognition through interaction with CD2 on T lymphocytes [1]. It is a member of the immunoglobulin superfamily of molecules. CD58 has a wide tissue distribution, being present on erythrocytes, platelets, monocytes, a subset of lymphocytes, bone marrow cells, epithelium and endothelial cells [2]. There are approximately 5000 CD58 molecules on each erythrocyte. There is reduced expression of CD58 on hemopoietic cells in individuals with paroxysmal nocturnal hemoglobinuria. Applications: Suitable for use in Flow Cytometry, Immunohistochemistry and Immunoprecipitation. Other applications not tested. Recommended Dilution: Flow Cytometry: 1:10-1:50; 10ul labels 10e6 cells in 100ul. Immunohistochemistry: Frozen sections Optimal dilutions to be determined by the researcher. Recommended Secondary Antibodies: I1904-06C: IgG, H&L (HRP) (X-Adsorbed) Pab Gt x Mo I1904-06H: IgG, H&L (HRP) (X-Adsorbed) Pab Gt x Mo I1904-14C: IgG, Fc (HRP) Pab Gt x Mo I1904-19C: IgG, F(ab
Catalogue number: C2412-06T
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry, Immunoprecipitation
Size: 100ug
Form: Supplied as a liquid, 0.09% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein A affinity chromatography.
References: 1. Makgoba, M.W., et al., Immunology Today 10: 417-422 (1989). 2. Shaw, S. & Johnson, J.P., (1989) In Leukocyte Typing IV: White Cell Differentiation Antigens. Edited by Knapp, W., Dorken, B., Gilks, W.R., Rieber, E.P., Schmidt, R.E., Stein, H. and von dem Borne, A.E.G.Kr. Oxford University Press. pp 714-716, 3. Grundy, J.E., et al., Immunology 78: 413-420 (1993).
Additional info: Recognizes human CD58.

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