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CD6 (CD6 molecule, FLJ44171, T12, T-cell differentiation antigen CD6, Tp120, TP120)

CD6 (CD6 molecule, FLJ44171, T12, T-cell differentiation antigen CD6, Tp120, TP120)

Cat no: C2257-05K

Supplier: United States Biological
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CD6 is a monomeric T-cell surface glycoprotein that is involved in T-cell activation (1). It is predominantly expressed on thymocytes, subpopulations of B-cells, and mature T-cells. Through its binding to activated leukocyte cell adhesion molecule (ALCAM/CD166), CD6 is considered to play an important role in lymphocyte development and activation. CD6 is a constitutively phosphorylated molecule that becomes hyperphosphorylated by serum and protein kinase C (PKC) activators, causing a molecular mass shift from 105 to 130 kDa (2,3). Applications: Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:1000-10,000 Immunohistochemistry: 1:250-500 Immunoprecipitation: 1:10-100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: C2257-05K
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50mM Tris-Glycine pH 7.4, 0.15M NaCl, 0.05% BSA, 0.01% sodium azide, 40% glycerol.
P type: Mab
Purity: Supernatant
References: 1. Bajorath J, et al. Protein Sci 4(8): 1644-7, 1995 2. Robinson WH, et al. Eur J Immunol 25(10):2765-9, 1995 3. Ibanez A, et al. J Immunol 177(2): 1152-9, 2006
Additional info: Recognizes human CD6.

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