ITGB3 protein is the integrin beta chain beta 3. Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. AlphaIIbeta3 and alphaVbeta3 are the two beta3 containing integrins, which are prominently expressed in hematopoitic cells and angiogenic endothelic cells and perform adhesive functions in hemostasis, wound healing and angiogenesis. ITGB3 localizes in the 17q21.32 region of chromosome. Alternate splicing of ITGB3 produces three isoforms, Beta-3A, Beta-3B and Beta-3C. Isoform beta-3A is specifically expressed in osteoblast cells and isoform beta-3C is specifically expressed in prostate and testis. Defects in ITGB3 are a cause of Glanzmann thrombasthenia (GT).
Applications:
Suitable for use in Immunohistochemistry. Other applications not tested.
Recommended Dilution:
Immunohistochemistry (paraffin): 10ug/ml
Optimal dilutions to be determined by the researcher.
Positive Control:
Placenta, terminal villi, red blood cells
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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