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CD61 (Integrin beta-3, Platelet Membrane Glycoprotein IIIa, GPIIIa, ITGB3, GP3A)

CD61 (Integrin beta-3, Platelet Membrane Glycoprotein IIIa, GPIIIa, ITGB3, GP3A)

Cat no: C2414-21U

Supplier: United States Biological
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CD61, a 105kD glycoprotein, is also known as integrin beta 3 chain. This molecule associates with either the alpha IIb integrin (CD41) or the alpha V integrin (CD51) at the cell surface. CD61 is expressed on platelets and megakaryocytes in association with CD41 and on endothelial cells, monocytes, platelets and osteoclasts in association with CD51. CD61 is a receptor for fibrinogen, fibronectin, vWF, vitronectin and thrombospondin. Applications: Suitable for use in Flow Cytometry and Immunohistochemistry. Other applications not tested. Recommended Dilution: Flow Cytometry: 1:100-1:200 Immunohistochemistry: Frozen and Paraffin Optimal dilutions to be determined by the researcher. Hybridoma: NS1 myeloma cells with spleen cells from Balb/c mice. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2414-21U
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry
Size: 200ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography.
References: 1. Phillips, D.R., et al., (1991), "GPIIb-IIIa: the responsive integrin", Cell, 65: 359-362. 2. Hynes, R.O., (1992), "Integrins: versatility, modulation, and signaling in cell adhesion", Cell, 69: 11-25. 3. Michelson, A.D., et al., (1995), "A panel of platelet MAb for the study of haemostasis and thrombosis in baboons", Leucocyte Typing V, Oxford University Press, p. 1230-1231. 4. Gatter, K., et al., (1998), "The immunohistological detection of platelets, megakaryocytes and thrombi in routinely processed specimens", Histopathology, 13: 257-267.
Additional info: Recognizes human CD61.

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