Home  >  Products  >  CD61 (Integrin, beta3, ITGB3, GP3A, GPIIIa, HPA-1, NAIT, Platelet Fibrinogen Receptor beta Subunit, Platelet Glycoprotein IIIa, Platelet Membrane Glycoprotein IIIa)
CD61 (Integrin, beta3, ITGB3, GP3A, GPIIIa, HPA-1, NAIT, Platelet Fibrinogen Receptor beta Subunit, Platelet Glycoprotein IIIa, Platelet Membrane Glycoprotein IIIa)

CD61 (Integrin, beta3, ITGB3, GP3A, GPIIIa, HPA-1, NAIT, Platelet Fibrinogen Receptor beta Subunit, Platelet Glycoprotein IIIa, Platelet Membrane Glycoprotein IIIa)

Cat no: C2414-21D

Supplier: United States Biological
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CD61 is a 110kD integrin b chain also known as b3 integrin or gpIIIa. It associates with the integrin av chain (CD51) to form the vitronectin receptor. In addition, CD61 can associate with the integrin aIIb chain (CD41) to form the gpIIb/IIIa complex. CD61 is expressed on platelets, megakaryocytes, endothelium, smooth muscle, a subset of B cells, myeloid cells, osteoclasts, and mast cells. CD61, in conjunction with CD41 or CD51, mediates adhesion to fibronectin, fibrinogen, vitronectin, thrombospondin, and von Willebrand factor. Leukocyte-endothelial adhesion is mediated by the binding of av/b3 integrin or vitronectin receptor to CD31 (PECAM-1). This antibody reacts with mouse and rat CD61, and is able to block ligand binding. Applications: Suitable for use in Flow Cytometry and Immunohistochemistry. Other applications not tested. Recommended Dilution: Flow Cytometry: (same/less than)1ug/10e6 cells in 100ul volume Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2414-21D
Reactivities: Mouse, Rat
Applications: Flow Cytometry, Immunohistochemistry
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook. Academic Press. 2. Phillips DR, et al. 1991. Cell 65:359. 3. Felding-Habermann B, et al. 1993. Curr. Opinion Cell Biol. 5:864.
Additional info: Recognizes mouse CD61. Species Crossreactivity: rat.

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