Home  >  Products  >  CD62L (L-selectin, CD62 Antigen-like Family Member L, Leukocyte Adhesion Molecule 1, LAM-1, Leukocyte Surface Antigen Leu-8, Leukocyte-endothelial Cell Adhesion Molecule 1, LECAM1, Lymph Node Homing Receptor, TQ1, gp90-MEL, SELL, LNHR, LYAM1)
CD62L (L-selectin, CD62 Antigen-like Family Member L, Leukocyte Adhesion Molecule 1, LAM-1, Leukocyte Surface Antigen Leu-8, Leukocyte-endothelial Cell Adhesion Molecule 1, LECAM1, Lymph Node Homing Receptor, TQ1, gp90-MEL, SELL, LNHR, LYAM1)

CD62L (L-selectin, CD62 Antigen-like Family Member L, Leukocyte Adhesion Molecule 1, LAM-1, Leukocyte Surface Antigen Leu-8, Leukocyte-endothelial Cell Adhesion Molecule 1, LECAM1, Lymph Node Homing Receptor, TQ1, gp90-MEL, SELL, LNHR, LYAM1)

Cat no: C2414-93S

Supplier: United States Biological
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CD62L is a 74-95 kD single chain type I glycoprotein referred to as L-selectin or LECAM-1. It is expressed on most peripheral blood B cells, subsets of T and NK cells, monocytes, granulocytes, and certain hematopoietic malignant cells. CD62L binds to carbohydrates present on certain glycoforms of CD34, glycam-1, and MAdCAM-1 and with a low affinity to anionic oligosaccharide sequences related to sialylated Lewis x (sLex, CD15s) through its C-type lectin domain. CD62L is important for the homing of naive lymphocytes to high endothelial venules in peripheral lymph nodes and Peyer's patches. It also plays a role in leukocyte rolling on activated endothelial cells. Applications: Suitable for use in Flow Cytometry, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Flow Cytometry: (same/less than)0.5ug per 10e6 cells in 100ul or 100ul whole blood. Immunohistochemistry: Reported to stain acetone-fixed frozen tissue sections. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2414-93S
Reactivities: Human, Bovine
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG1,k
Purity: Purified by affinity chromatography.
References: 1. Schlossman, S., et al. Eds. 1995. Leucocyte Typing V. Oxford University Press. New York. 2. Kishimoto, T., et al. 1990. PNAS 87:2244. 3. Jutila, M., et al. 2002. J. Immunol. 169:1768. 4. Tamassia, N., et al. 2008. J. Immunol. 181:6563. 5. Kmieciak, M., et al. 2009. J. Transl. Med. 7:89. (FC) 6. Thakral, D., et al. 2008. J. Immunol. 180:7431. (FC) 7. Charles, N., et al. 2010. Nat. Med. 16:701. (FC) 8. Yoshino, N., et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC) 9. Kishimoto, T., et al. 1990. PNAS 87:2244. 10. Kishimoto T., et al. 1991. Blood 78:805.
Additional info: Recognizes human CD62L. Species Crossreactivity: chimpanzee and bovine

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