CD62p, Recombinant, Human (LECAM, P-Selectin, Endothelial Leukocyte Adhesion Molecule)

P-Selectin (Platelet Alpha-Granule Membrane Protein/CD62/Granulocyte Membrane Protein GRMP) belongs to a family of divalent cation-dependent carbohydrate-binding glycoproteins or adhesion molecules. Pselectin is expressed transiently on the surface of activated platelets and endothelial cells. Secreted P-selectin is thought to play a key role in the adhesion of platelets to monocytes and neutrophils during an inflammatory response. Levels of P-Selectin may be elevated in a number of pathological conditions.\n\nDescription: \nRecombinant Human P-Selectin is expressed in E. coli containing 566 amino acids 197-761 fused to an amino terminal hexahistidine tag.\n\nApplications: \nRecombinant P-Selectin can be used directly as a positive control in Western blotting, ELISA, immunoprecipitation and other immunological experiments. The biological activity of this product has not yet been tested.\n\nStability: \nStore at 4 degrees C if entire vial will be used within 1-2 weeks. Store, frozen at -20 degrees C for longer periods of time. Please avoid freeze-thaw cycles.

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SPECIFICATIONS

Catalog Number

C2415-50H

Size

2ug

Form

Supplied as a liquid in 1X Laemmli Buffer (25mM Tris-HCl, pH 6.8, 50mM DTT, 1% SDS, 0.1% Bromophenol Blue and 2.5% glycerol).

Purity

(same/more than) 95% (SDS-PAGE). Single band on Western Blot.

References

1. LDL-Apheresis Reduces P-Selectin, CRP and Fibrinogen- Possible Important Implications for Improving Atherosclerosis.\n\nTher Apher Dial 2006 Jun;10(3):219-223\n\n2. 12(S)-HETE plays a role as a mediator of expression of platelet CD62 (P-selectin).\n\nPlatelets 1998 Oct;9(5):297-302\n\n3. Effects of acute myelogenous leukemia blasts on platelet release of soluble P-selectin and platelet-derived growth factor.\n\nPlatelets 1998 Dec;9(6):352-8\n\n4. Activation of leukocytes in whole blood samples by N-formyl-methionyl-leucyl-phenylalanine (FMLP) enhances platelet aggregability but not platelet P-selectin exposure and adhesion to leukocytes.\n\nPlatelets 1998 Jul;9(3):219-21\n\n5. Von Willebrand factor, P-selectin and fibrinogen levels in patients with acute ischaemic and haemorrhagic stroke, and their relationship with stroke sub-type and functional outcome.\n\nPlatelets 1998 Jul;9(3):155-9\n\n6. The influence of various structural parameters of semisynthetic sulfated polysaccharides on the P-selectin inhibitory capacity.\n\nBiochem Pharmacol 2006 May 13;