Home  >  Products  >  CD63 (CD63 Antigen, Granulophysin, Lysosome-associated Membrane Glycoprotein 3, LAMP-3, ME491, Melanoma 1 Antigen, MLA1, Melanoma-associated Antigen ME491, Ocular Melanoma-associated Antigen, OMA81H, Tetraspanin-30, TSPAN30, Tspan-30)
CD63 (CD63 Antigen, Granulophysin, Lysosome-associated Membrane Glycoprotein 3, LAMP-3, ME491, Melanoma 1 Antigen, MLA1, Melanoma-associated Antigen ME491, Ocular Melanoma-associated Antigen, OMA81H, Tetraspanin-30, TSPAN30, Tspan-30)

CD63 (CD63 Antigen, Granulophysin, Lysosome-associated Membrane Glycoprotein 3, LAMP-3, ME491, Melanoma 1 Antigen, MLA1, Melanoma-associated Antigen ME491, Ocular Melanoma-associated Antigen, OMA81H, Tetraspanin-30, TSPAN30, Tspan-30)

Cat no: C2418-03B

Supplier: United States Biological
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CD63, also known as LAMP-3 or ME491 (melanoma- associated antigen), is a member of the tetraspanin superfamily of protein trafficking proteins. CD63 is ubiquitously expressed and found in late endocytic vesicles, but following cell activation is also present on the plasma membrane. CD63 interacts with other membrane proteins or adaptors to regulate activities such as adhesion, migration and degranulation. The 238aa CD63 migrates at 30-60kD, depending on post-translational modification. Extracellular regions of mouse CD63 share 94% and 67% aa identity with rat and human CD63, respectively. Applications: Suitable for use in Indirect Immunofluorescence, Flow Cytometry, Fluorescent Microscopy, Detection of activated platelets and Thrombus imaging. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2418-03B
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunofluorescence
Size: 1ml
Form: Supplied as a liquid in 20mM TRIS, 150mM sodium chloride, pH 8, 10mg BSA, 0.001% Mertiolate.
P type: Mab
Isotype: IgG1
Purity: Purified by affinity chromatography.
Alternative names: CD63 Molecule, Lysosome-associated Membrane Protein 3, LAMP 3, LAMP3, Mast Cell Antigen AD1, Melanoma-associated Antigen ME491, Melanoma-associated Antigen MLA1, MGC72893
References: 1. Modderman, P.W., in Leukocyte Typing IV (W. Knapp et al., eds.), p. 1042.
Additional info: Recognizes human CD63, a 53kD glycoprotein. Expressed in platelet lysosomes, that are located to the platelet surface upon activation with strong agonists. Also present in most peripheral blood cells (not in erythrocytes cells) and in many tissues; both surface and cytoplasmic locations are reported.

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