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CD63 (Granulophysin, Lysosomal-associated Membrane Protein 3, LAMP-3, Melanoma-associated Antigen ME491, OMA81H, Ocular Melanoma-associated Antigen, Tetraspanin-30, Tspan-30, MLA1, TSPAN30)

CD63 (Granulophysin, Lysosomal-associated Membrane Protein 3, LAMP-3, Melanoma-associated Antigen ME491, OMA81H, Ocular Melanoma-associated Antigen, Tetraspanin-30, Tspan-30, MLA1, TSPAN30)

Cat no: C2418-09M

Supplier: United States Biological
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CD63, also known as LAMP-3 or ME491 (melanoma- associated antigen), is a member of the tetraspanin superfamily of protein trafficking proteins. CD63 is ubiquitously expressed and found in late endocytic vesicles, but following cell activation is also present on the plasma membrane. CD63 interacts with other membrane proteins or adaptors to regulate activities such as adhesion, migration and degranulation. The 238aa CD63 migrates at 30-60kD, depending on post-translational modification. Extracellular regions of mouse CD63 share 94% and 67% aa identity with rat and human CD63, respectively. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry: 10ul labels 1x10e6 cells in 100ul Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2418-09M
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry
Size: 200ug
Form: Supplied as a liquid in PBS, 0.09% sodium azide, 1% bovine.
P type: Mab
Isotype: IgG1
Purity: Purified
References: 1. Casey, T. et al. (2007) Organelle proteomics: identification of the exocytic machinery associated with the natural killer cell secretory lysosome. Mol. Cell. Proteomics 6: 767-780.
Additional info: Recognizes human CD63.

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