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CD64 (Fc receptor, IgG, high affinity)

CD64 (Fc receptor, IgG, high affinity)

Cat no: C2419-06Q

Supplier: United States Biological
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Human CD64 is a high affinity receptor for monomeric human IgG1 and IgG3 which is expressed on macrophages, monocytes, and gamma interferon induced neutrophils. CD64 plays an important role in clearance of immune complexes and in antibody dependent cytoxicity. Applications: Suitable for use in Western Blot and Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry: 5x10e5 cultured U-937 cells were washed and incubated 45 min on ice with 80ul of anti-CD64 antibody at 10ug/ml. Cells were washed twice and incubated with Goat anti-Mouse IgG/FITC, after which they were washed three times, fixed and analyzed by FACS. Cells stained positive with a mean shift of 0.65 log10 fluorescent units when compared to a Mouse IgG1 negative control at a similar concentration. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2419-06Q
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Western Blot
Size: 100ug
Form: Supplied as a liquid in 50mM sodium phosphate, pH 7.5, 100mM potassium chloride, 150mM sodium chloride.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein A affinity chromatography.
References: 1. G.J. Dougherty, et al, (1987) Eur J Immunol 17:1453-1459, 2. Y. Jayaram, et al, (1989) Clin Exp Immunol 75:414-420, 3. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 874-875, 4. D.L. Durden, et al, (1995) J Immunol 154:4039-4047, 5. L.L. Marnell, et al, (1995) J Immunol 155:2185-2193, 6. S. von Gunten, H.U. Simon, et al. (2006) Blood 108(13):4255-425.
Additional info: Recognizes the human CD64 molecule of 72kD from gene FcyRIA. Blocks binding of FcyRI to immunoglobin opsonized cells.

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