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CD68 (DKFZp686M18236, GP110, Macrophage Antigen CD68 (Microsialin), Macrosialin, Scavenger Receptor Class D Member 1, SCARD1)

CD68 (DKFZp686M18236, GP110, Macrophage Antigen CD68 (Microsialin), Macrosialin, Scavenger Receptor Class D Member 1, SCARD1)

Cat no: C2423-05R

Supplier: United States Biological
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CD68, an 110kD Type I integral membrane glycoprotein, is a member of Lysosome-associated membrane protein (LAMP) family. It belongs to the family of hematopoietic mucin-like molecules and is predominantly expressed on monocytes and tissue macrophages, dendritic cells, granulocytes, activated T-cells and subset of B-cells. Its heavily glycosylated extracellular domain consists of a mucin domain separated from the LAMP domain by a proline-rich spacer region. It physiological function has been elusive but reports suggest its role in binding and uptake of oxidized LDLs accumulated in macrophage-derived foam cells within atherosclerotic plaques. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (frozen): 1:100-1:150 Optimal dilutions to be determined by the researcher. Positive Control: Tonsil Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2423-05R
Reactivities: Human
Hosts: Mouse
Applications: Immunohistochemistry
Size: 500ul
Form: Supplied as a liquid, 0.05% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Supernatant
References: 1. Kelly et al. J Clin Pathol 41: 510, 1988. 2. Micklem et al. Br J Haematol 73: 6, 1989. 3. Pulford et al. Int Immunol 2: 973, 1990. 4. Kelly et al. J Clin Pathol 41: 1305, 1988. 5. Ramprasad et.al PNAS 93;14833-14838 (December 1996).
Additional info: Recognizes human CD68.

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