Home  >  Products  >  CD69 (Early Activation Antigen CD69, Activation Inducer Molecule, AIM, BL-AC/P26, C-type Lectin Domain Family 2 Member C, EA1, Early T-cell Activation Antigen p60, GP32/28, Leukocyte Surface Antigen Leu-23, MLR-3, CLEC2C)
CD69 (Early Activation Antigen CD69, Activation Inducer Molecule, AIM, BL-AC/P26, C-type Lectin Domain Family 2 Member C, EA1, Early T-cell Activation Antigen p60, GP32/28, Leukocyte Surface Antigen Leu-23, MLR-3, CLEC2C)

CD69 (Early Activation Antigen CD69, Activation Inducer Molecule, AIM, BL-AC/P26, C-type Lectin Domain Family 2 Member C, EA1, Early T-cell Activation Antigen p60, GP32/28, Leukocyte Surface Antigen Leu-23, MLR-3, CLEC2C)

Cat no: C2424-10J

Supplier: United States Biological
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CD69 is a 27-33 kD type II transmembrane protein, also known as activation inducer molecule (AIM), very early activation antigen (VEA), and MLR3. It is a member of the C-type lectin family, expressed as a disulfide-linked homodimer. Other members of this receptor family include NKG2, NKR-P1 CD94, and Ly49. CD69 is transiently expressed on activated leukocytes including T cells, thymocytes, B cells, NK cells, neutrophils, and eosinophils. CD69 is constitutively expressed by a subset of medullary mature thymocytes, platelets, mantle B cells and certain CD4+ T cells in germinal centers of normal lymph nodes. CD69 is involved in early events of lymphocyte, monocyte, and platelet activation, and has a functional role in redirected lysis mediated by activated NK cells. Applications: Suitable for use in Flow Cytometry, Immunofluorescence and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2424-10J
Reactivities: Human, Mollusc
Hosts: Mouse
Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG1,k
Purity: Purified by immunoaffinity chromatography.
References: 1. Knapp, W., B et al. 1989. Leucocyte Typing IV. Oxford University Press. New York. 2. Sakkas, L. I., et al. 1998. Clin. and Diag. Lab. Immunol. 5:430. 3. Kim, J. R., et al. 2005. BMC Immunol. 6:3. 4. Verjans, G. M., et al. 2007. PNAS 104:3496. 5. Lu, H., et al. 2009. Toxicol Sci. 112:363. 6. Thakral, D., et al. 2008. J. Immunol. 180:7431. (FC) 7. Yoshino, N., et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC) 8. Schlossman, S., et al. Eds. 1995. Leucocyte Typing V. Oxford University Press. New York. 9. Testi, R., et al. 1994. Immunol. Today 15:479.
Additional info: Recognizes human CD69. Species Crossreactivity: chimpanzee, baboon, cynomolgus, rhesus, pigtailed macaque.

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