CD7 (also known as gp40, Leu9) is a member of the immunoglobulin gene superfamily. It is expressed on the majority of immature and mature Tlymphocytes and T cell leukemia. It is also found on natural killer (NK) cells, a small subpopulation of normal B cells and on malignant B cells. Cross-linking surface CD7 positively modulates T cell and NK cell activity as measured by calcium fluxes, expression of adhesion molecules, cytokine secretion and proliferation. CD7 associates directly with phosphoinositol 3'-kinase. CD7 ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation. Primitive T cell neoplasms such as lymphoblastic leukemia express CD7 antigen.
Applications:
Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution:
Western Blot: 1ug/ml for 2h at RT
Optimal dilutions to be determined by the researcher.
Positive Control:
CEM T cell line or Jurkat
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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