Home  >  Products  >  CD71 (CD71 Antigen, p90, T9, Transferrin Receptor, TFR, TR, Transferrin Receptor Protein 1, TFR 1, TFR1, TFR-1, TFRC, TRFR)
CD71 (CD71 Antigen, p90, T9, Transferrin Receptor, TFR, TR, Transferrin Receptor Protein 1, TFR 1, TFR1, TFR-1, TFRC, TRFR)

CD71 (CD71 Antigen, p90, T9, Transferrin Receptor, TFR, TR, Transferrin Receptor Protein 1, TFR 1, TFR1, TFR-1, TFRC, TRFR)

Cat no: C2426-02K

Supplier: United States Biological
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CD71, also designated transferrin receptor 1, is a homodimeric type II membrane glycoprotein of 90-95kD. This receptor binds two molecules of the serum iron-transport protein transferrin (TF) and is internalized into endosomes that are acidified, resulting in the release of iron from TF. CD71 is not expressed on resting leukocytes but is upregulated on all proliferating cells upon activation, reflecting the iron dependence of proliferation. In tissues CD71 is expressed on most dividing cells and on brain capillary endothelium. Expression of CD71 is down regulated as a result of iron overload. CD71 shares 45% identity with human transferrin receptor 2. Applications: Suitable for use in Flow Cytometry, ELISA, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Flow Cytometry: 1:10 Western Blot: 1:10 Immunohistochemistry (Frozen): 1:10 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2426-02K
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide, 0.1% BSA.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography.
References: 1. Vogt, T., et al., Blood 101: 2008 (2003). 2. Johnson, M., et al., Blood 104: 4287 (2004).
Additional info: Recognizes human CD71. Does not inhibit the biological activity of TfR1.

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