Home  >  Products  >  CD71 (CD71 Antigen, p90, T9, Transferrin Receptor, TFR, TR, Transferrin Receptor Protein 1, TFR 1, TFR1, TFR-1, TFRC, TRFR)

CD71 (CD71 Antigen, p90, T9, Transferrin Receptor, TFR, TR, Transferrin Receptor Protein 1, TFR 1, TFR1, TFR-1, TFRC, TRFR)

Cat no: C2426-15J


Supplier: United States Biological
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The balance between a sufficient amount of iron uptake and prevention of accumulation of excess iron within a cell, is vitally important to maintain cellular functions such as oxygen and electron transport and mitochondrial energy metabolism, whilst preventing permanent cell and tissue damage. Transferrin receptor (CD71), transferrin and ferritin have been identified as specialised proteins which control the uptake, transport and storage of free iron in tissues, thereby maintaining iron homeostasis. An imbalance in iron homeostasis within the brain has been linked with the neurodegenerative diseases, Alzheimer
Catalogue number: C2426-15J
Reactivities: Rat
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry, Western Blot
Size: 500ug
Form: Supplied as a liquid in PBS. No preservative added.
P type: Mab
Isotype: IgG2a
Purity: Purified by Protein G affinity chromatography.
References: 1. Jefferies, W.A. et al. (1985) Analysis of lymphopoietic stem cells with a monoclonal antibody to the rat transferrin receptor. Immunology 54: 333-341.2. Yefimova, M.G. et al. (1984) Impaired retinal iron homeostasis associated with defective phagocytosis in Royal College of Surgeons rats. Inv. Opth. & Vis. Sci. 43: 537-545.3. Jefferies, W.A. et al. (1984) Transferrin receptor on endothelium of brain capillaries. Nature 312: 162-163.4. Lipardi, C. et al. (2002) Differential recognition of a tyrosine-dependent signal in the basolateral and endocytic pathways of thyroid epithelial cells. Endocrinology. 143: 1291-1301.
Additional info: Recognizes rat CD71, also known as transferrin receptor, a homodimeric type II transmembrane protein, expressed by all proliferating cells and cells with a requirement for iron, including reticulocytes and capillary endothelium in brain. Also binds to a number of non-dividing normal tissues.

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