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CD72 (B-cell Differentiation Antigen CD72, Lyb-2)

CD72 (B-cell Differentiation Antigen CD72, Lyb-2)

Cat no: C2428-41E

Supplier: United States Biological
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CD72, a human homolog of murine Lyb-2, is a 45kD B-cell transmembrane glycoprotein. It is expressed in all stages of B-cell development except plasma cells and functions as a vital B-cell co-receptor. It exhibits a dual role during B-cell activation and development. It mediates positive signaling through activation of Grb2-Sos-Ras pathway resulting in activation of several downstream pathways including ERK and JNK pathways. ITIM motif present in the cytoplasmic domain of CD72 recruits SHP-1 upon tyrosine phosphorylation, resulting in negative regulation of BCR signaling. CD72 functions as a novel receptor for CD100/Sema4D, resulting in dephosphorylation of CD72 and regulation of negative signaling by CD72. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2428-41E
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
References: 1. Von Hoegen et al. (1990). J Immunol 144(12):4870-7. 2. Adachi et.al J Immunol., 160(10):4662-5 (1998 May 15). 3. Wu HJ et.al J Immunol., 167(3):1263-73 (2001 Aug 1). 4. Kumanogoh et.al Immunity 13(5):621-31 (2000 Nov).
Additional info: Recognizes human CD72.

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