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CD79a (B-cell Antigen Receptor Complex-associated Protein alpha-chain)

CD79a (B-cell Antigen Receptor Complex-associated Protein alpha-chain)

Cat no: C2431-01D1

Supplier: United States Biological
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CD79a (mb-1/ B lymphocyte-specific MB-1 protein) was originally identified on the basis of its restricted expression in lymphocytes of B lineage (1). CD79a associates with surface IgM-receptors; it has been implicated in the signal transduction pathways and in the regulation of type of type 2A-related serine/threonine phosphatases catalytic activity (2). A disulfide-linked heterodimer, consisting of CD79a (mb-1) and CD79b / B29 polypeptides, non-covalently associates with membrane-bound immunoglobulins on B cells to constitute the B cell Ag receptor.CD79 is required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also CD79 interacts with and increases activity of some Src-family tyrosine kinases. (3). Applications: Suitable for use in Flow Cytometry, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Flow Cytometry: 1:140 Western Blot: 1:5000-1:20,000 Immunohistochemistry: 1:100-1:250 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: C2431-01D1
Reactivities: Human
Hosts: Rabbit
Applications: Flow Cytometry, Immunohistochemistry, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50mM Tris-Glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA.
P type: Mab
Isotype: IgG
Purity: Supernatant
Alternative names: B Cell Antigen Receptor Complex Associated Protein alpha Chain Precursor, B Lymphocyte Specific MB1 Protein, CD79A Antigen Immunoglobulin-associated alpha, Ig alpha, IGA, Immunoglobulin Associated Alpha, Ly54, MB1 Membrane Glycoprotein, Surface IgM-associated Protein
References: 1. Mason DY et al. Blood 86(4):1453-1459,1995. 2. Nanahoshi M et al. FEBS Lett. 5;446(1):108-112, 1999. 3. The UniProt Consortium, The Universal Protein Resource (UniProt), Nucleic Acids Res. 36:D190-D195 (2008)
Additional info: Recognizes human CD79a protein.

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