Home  >  Products  >  CD79a (B-cell Antigen Receptor Complex-associated Protein alpha Chain, Ig-alpha, IGA, MB1, MB-1, MB-1 Membrane Glycoprotein, Membrane-bound Immunoglobulin-associated Protein, Surface IgM-associated Protein)
CD79a (B-cell Antigen Receptor Complex-associated Protein alpha Chain, Ig-alpha, IGA, MB1, MB-1, MB-1 Membrane Glycoprotein, Membrane-bound Immunoglobulin-associated Protein, Surface IgM-associated Protein)

CD79a (B-cell Antigen Receptor Complex-associated Protein alpha Chain, Ig-alpha, IGA, MB1, MB-1, MB-1 Membrane Glycoprotein, Membrane-bound Immunoglobulin-associated Protein, Surface IgM-associated Protein)

Cat no: C2431-10N

Supplier: United States Biological
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CD79a, a 32-33 kD membrane glycoprotein, is a member of Ig superfamily. It heterodimerizes with CD79b and is non-covalently cross-linked with surface Ig thus forming the BCR complex. It is expressed all stages of differentiation in mature B-cells and is required for cell surface expression and signal transduction by the BCR complex. Upon antigen binding, CD79a/b heterodimer interacts with Tyrosine kinase (Lyn) and gets phosphorylated, resulting in the inititation of intracellular signaling cascade. Pathological role of CD79a has been suggested in B-cell lymphomas and acute lymphoblastic leukemia. CD79a is often used along with CD20 in the detection of normal and neoplastic B-cells in tissue sections. 1. Flaswinkel et.al Immunogenetics 36(4):266-9 (1992) 2. Koyama et.al Int Immunol., 9(11):1767-72 (1997 Nov). Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin): 1:50-1:100 Optimal dilutions to be determined by the researcher. Positive Control: Tonsil Cellular Localization: Cell membrane Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2431-10N
Reactivities: Human, Mouse, Bovine, Canine, Chicken/Bird, Guinea Pig, Non-Human Primate, Porcine, Rabbit
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 500ul
Form: Supplied as a liquid in 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Serum
Alternative names: CD79a Molecule, Immunoglobulin-associated alpha
References: 1. Flaswinkel et.al Immunogenetics 36(4):266-9 (1992). 2. Koyama et.al Int Immunol., 9(11):1767-72 (1997 Nov).
Additional info: Recognizes CD79a. Species Crossreactivity: Bovine, canine, chicken, equine, guinea pig, human, monkey, mouse and porcine.

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