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CD79b (B-cell Antigen Receptor Complex-associated Protein beta Chain, B-cell-specific Glycoprotein B29, Ig-beta, Immunoglobulin-associated B29 Protein, B29, IGB)

CD79b (B-cell Antigen Receptor Complex-associated Protein beta Chain, B-cell-specific Glycoprotein B29, Ig-beta, Immunoglobulin-associated B29 Protein, B29, IGB)

Cat no: C2431-01X

Supplier: United States Biological
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The CD79 molecule, comprising two polypeptide chains, mb-1 (CD79a) and B29 (CD79b), is physically associated in the B-cell membrane with immunoglobulins to constitute the B cell antigen receptor (BCR). The CD79a/b heterodimer interacts with at least one tyrosine kinase (Lyn). Induction of tyrosine kinase activity after antigen binding causes phosphorylation of the CD79a/b dimer, and also of other molecules, thereby initiating intracellular signaling. Almost all acute lymphoblastic leukemias of precursor B cell type are positive when tested with CD79a antibodies. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2431-01X
Reactivities: Mouse
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Payelle-Brogard. et al. Brit J Hematology 118, 976 (2002). 2. Chu, P. et al. Appl Immunohistochem Mol Morphol 9, 97 (2001). 3. Payelle-Brogard, B. et al. Blood 94, 3516 (1999). 4. Mason, D. et al. Blood 86, 1453 (1995). 5. Verschuren, M. et al. Leukemia 7, 1931 (1993). 6. Buccheri, V. et al. Blood 82, 853 (1993).
Additional info: Recognizes mouse CD79b.

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