Home  >  Products  >  CD80 (T-lymphocyte Activation Antigen CD80, Activation B7-1 Antigen, B7, B7.1, B71, B7-1, Cd28l, Ly53, Ly-53, MIC17, TSA1)
CD80 (T-lymphocyte Activation Antigen CD80, Activation B7-1 Antigen, B7, B7.1, B71, B7-1, Cd28l, Ly53, Ly-53, MIC17, TSA1)

CD80 (T-lymphocyte Activation Antigen CD80, Activation B7-1 Antigen, B7, B7.1, B71, B7-1, Cd28l, Ly53, Ly-53, MIC17, TSA1)

Cat no: C2432-14F

Supplier: United States Biological
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CD80 is a 60kD highly glycosylated protein. It is a member of the Ig superfamily, also known as B7-1, B7 and Ly-53. CD80 is constitutively expressed on dendritic cells and monocytes/macrophages, and inducibly expressed on activated B and T cells. The ligation of CD28 on T cells with CD80 and CD86 (B7-2) on antigen presenting cells (such as dendritic cells, macrophages, and B cells) elicits co-stimulation of T cells resulting in enhanced cell activation, proliferation, and cytokine production. CD80 appears to be expressed later in the immune response than CD86. CD80 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells. Applications: Suitable for use in Flow Cytometry, Immunohistochemistry and Immunoprecipitation. Other applications not tested. Recommended Dilution: Flow Cytometry: (same/less than)1ug/10e6 cells in 100ul volume Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2432-14F
Reactivities: Mouse, Canine
Applications: Flow Cytometry, Immunohistochemistry, Immunoprecipitation
Size: 500ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press. 2. Linsley PS, et al. 1991. J. Exp. Med. 174:561. 3. Salomon B, et al. 2001. Annu. Rev. Immunol. 19:225.
Additional info: Recognizes mouse CD80. Species Crossreactivity: canine.

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