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CD80 (T-lymphocyte Activation Antigen CD80, Activation B7-1 Antigen, BB1, CTLA-4 Counter-receptor B7.1, B7, CD28LG, CD28LG1, LAB7)

CD80 (T-lymphocyte Activation Antigen CD80, Activation B7-1 Antigen, BB1, CTLA-4 Counter-receptor B7.1, B7, CD28LG, CD28LG1, LAB7)

Cat no: C2432-04K

Supplier: United States Biological
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CD80 is a 60 kD single chain type I glycoprotein belonging to the immunoglobulin superfamily, also known as B7-1, B7, and BB1. CD80 is expressed on activated B and T cells, macrophages and dendritic cells. CD80 binds to CD28 and CD152 (CTLA-4). Along with CD86, CD80 plays a critical role in regulation of T cell activation. The interaction of CD80 with CD28 provides a potent co-stimulatory signal for T cell activation through the CD3 complex, while its interaction with CTLA-4 provides inhibitory signal for T cell activation. Applications: Suitable for use in Flow Cytometry, Western Blot, Immunoprecipitation and Immunohistochemistry.. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2432-04K
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG1,k
Purity: Purified by immunoaffinity chromatography.
References: 1. Kishimoto, T., et al. Eds. 1997. Leucocyte Typing VI. Garland Publishing Inc. London. 2. Battifora, M. 1998. J. Clin. Endocrin. & Metab. 83:4130. 3. Anton van der Merwe, P., et al. 1997. Exp. Med. 185:3. 4. Battifora, M., et al. 1998. J. Clin. Endocr. Meta. 83:4130. 5. Jayakumar, A., et al. 2008. Infect Immune. 76:2138. 6. Freeman, G., et al. 1991. J. Exp. Med. 174:625. 7. Linsley, P., et al. 1996. Immunity 4:535. 8. Linsley, P., et al. 1991. J. Exp. Med. 174:561.
Additional info: Recognizes human CD80.

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