CD80 is a 60kD single chain type I glycoprotein belonging to the immunoglobulin superfamily, also known as B7-1, B7, and BB1. CD80 is expressed on activated B and T cells, macrophages and dendritic cells. CD80 binds to CD28 and CD152 (CTLA-4). Along with CD86, CD80 plays a critical role in regulation of T cell activation. The interaction of CD80 with CD28 provides a potent co-stimulatory signal for T cell activation through the CD3 complex, while its interaction with CTLA-4 provides inhibitory signal for T cell activation.
Applications:
Suitable for use in Immunofluorescence, ELISA and Immunohistochemistry. Other applications not tested.
Recommended Dilution:
Immunofluorescence: 1:200-1:1000
Immunohistochemistry (Formalin fixed paraffin embedded): 1:200
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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