CD82 (CD82 Antigen, C33 Antigen, IA4, Inducible Membrane Protein R2, Metastasis Suppressor Kangai-1, Suppressor of Tumorigenicity 6 Protein, Tetraspanin-27, Tspan-27, KAI1, SAR2, ST6, TSPAN27)

Cat no: C2433-60H

Supplier: United States Biological

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KAI1 was initially identified from a T-cell activation study as a four-transmembrane protein that plays an accessory role in T-cell activation, and was later determined to act as a cancer metastasis suppressor gene. This protein is ubiquitously expressed at moderate to high levels in most tissues, but its expression is downregulated during tumor progression. The loss of KAI1 and p53 is associated with poor survival for prostate and other cancer patients. Recently, KAI1 was found to interact with DARC, the Duffy antigen for chemokines using a yeast two hybrid screen. It is thought that tumor cells dislodged from the primary tumor and expressing KAI1 interact with DARC proteins expressed on vascular cells, transmitting a senescent signal to the tumor cells, while tumor cells that have lost KAI1 expression can proliferate and potentially give rise to metastases. At least two isoforms of KAI1 are known to exist. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1ug/ml Optimal dilutions to be determined by the researcher. Positive Control: A549 cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Catalogue number:	C2433-60H
Reactivities:	Human, Mouse, Rat
Hosts:	Rabbit
Applications:	ELISA, Immunohistochemistry, Western Blot
Size:	50ug
Form:	Supplied as a liquid in PBS, 0.02% sodium azide.
P type:	Pab
Isotype:	IgG
Purity:	Purified
References:	1. HW Gaugitsch, et al (1991) Eur. J. Immunol. 21:377-83. 2. Gil ML, et al (1992) J. Immunol. 2826-33. 3. Dong JT, et al (1995) Science. 884-86. 4. Kauffman EC, et al (2003) J. Urol. 169:1122-33. 5. Bandyopadhyay S, et al (2006) Nature Med. 12:933-8.
Additional info:	Recognizes human KAI1. Species Crossreactivity: mouse and rat.

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CD82 (CD82 Antigen, C33 Antigen, IA4, Inducible Membrane Protein R2, Metastasis Suppressor Kangai-1, Suppressor of Tumorigenicity 6 Protein, Tetraspanin-27, Tspan-27, KAI1, SAR2, ST6, TSPAN27)

Cat no: C2433-60H

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