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CD83 (B-cell activation protein, BL11, Cell Surface Protein HB15)

CD83 (B-cell activation protein, BL11, Cell Surface Protein HB15)

Cat no: C2435-09

Supplier: United States Biological
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CD83 is a 45kD type 1 glyoprotein belonging to the immunoglobulin superfamily. Originally described as a maturation marker for dendritic cells, CD83 plays a role in the regulation of antigen presentation, thymic T-cell maturation, B-cell function and peripheral T-cell activation. Activated dendritic cells and B-cells release a soluble form of CD83 that is reported to have an immunosuppressive effect, suggesting a therapeutic role for sCD83 in the regulation of immune disorders. Applications: Suitable for use in Flow Cytometry and Western Blot. Not inhibitory to DC mediated T cell stimulation in mixed lymphocyte reactions. Other applications not tested. Recommended Dilutions: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2435-09
Reactivities: Human
Hosts: Rat
Applications: Flow Cytometry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.01% sodium azide.
P type: Mab
Isotype: IgG2a
Purity: Purified by Protein G affinity chromatography.
References: 1. The extracellular domain of CD83 inhibits dendritic cell-mediated T cell stimulation and binds to a ligand on dendritic cells: M. Lechmann, et al.; J. Exp. Med. 194, 1813 (2001) 2. Overexpression, purification, and biochemical characterization of the extracellular human CD83 domain and generation of monoclonal antibodies: M. Lechmann, et al.; Protein Exp. Purif. 24, 445 (2002).
Additional info: Recognizes human CD83. Deglycosylated CD83 is only weakly recognized.

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