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CD86 (T-lymphocyte Activation Antigen CD86, Activation B7-2 Antigen, B70, BU63, CTLA-4 Counter-receptor B7.2, FUN-1, CD28LG2)

CD86 (T-lymphocyte Activation Antigen CD86, Activation B7-2 Antigen, B70, BU63, CTLA-4 Counter-receptor B7.2, FUN-1, CD28LG2)

Cat no: C2438-05A

Supplier: United States Biological
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CD86 is an 80kD immunoglobulin superfamily member, also known as B7-2, B70, and Ly-58. CD86 is expressed on activated B and T cells, macrophages, dendritic cells and astrocytes. CD86 binds to CD28 to transduce co-stimulatory signals for T cell activation, proliferation, and cytokine production. The GL1 antibody can block the mixed lymphocyte reaction in vitro and has been shown to inhibit the priming of cytotoxic T lymphocytes in vivo (along with antibodies against B7-1). Applications: Suitable for use in Immunoprecipitation, Flow Cytometry, Immunofluorescence and Immunohistochemistry. Other applications not tested. Recommended Dilution: Flow Cytometry: (same/less than)0.25ug/10e6 cells in 100ul Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2438-05A
Reactivities: Mouse
Hosts: Rat
Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG2a,k
Purity: Purified by immunoaffinity chromatography.
References: 1. Hathcock, K.S., et al., 1993. Science 262:905. 2. Inaba, K., M., et al., 1994. J. Exp. Med. 180:1849. 3. Hathcock, K.S., et al., 1994. J. Exp. Med. 180:631. 4. Krummel, M.F., et al., 1995. J. Exp. Med. 182:459. 5. Liu, Y., et al., 1997. J. Exp. Med. 185:251. 6. Herold, K.C., et al., 1997. J. Immunol. 158:984. 7. Shih, F. F., et al., 2006. J. Immunol. 176:3438. 8. Lawson, B. R., et al., 2007. J. Immunol. 178:5366. 9. Turnquist, H.R., et al., 2007. J. Immunol. 178:7018.
Additional info: Recognizes mouse CD86.

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