Home  >  Products  >  CD86 (T-lymphocyte Activation Antigen CD86, Activation B7-2 Antigen, B70, BU63, CTLA-4 Counter-receptor B7.2, FUN-1, CD28LG2)
CD86 (T-lymphocyte Activation Antigen CD86, Activation B7-2 Antigen, B70, BU63, CTLA-4 Counter-receptor B7.2, FUN-1, CD28LG2)

CD86 (T-lymphocyte Activation Antigen CD86, Activation B7-2 Antigen, B70, BU63, CTLA-4 Counter-receptor B7.2, FUN-1, CD28LG2)

Cat no: C2438-26G

Supplier: United States Biological
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CD86 is an 80 kD immunoglobulin superfamily member, also known as B7-2, B70, and Ly-58. CD86 is expressed on activated B and T cells, monocytes/macrophages, dendritic cells and astrocytes. CD86 along with CD80 are the ligands of CD28 and CD152 (CTLA-4). CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce co-stimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can also bind to CD152, known as CTLA-4, to deliver an inhibitory signal to T cells. The IT2.2 antibody blocks T cell activation. Applications: Suitable for use in Flow Cytometry, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2438-26G
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG2b,k
Purity: Purified by immunoaffinity chromatography.
References: 1. Kishimoto, T., et al. Eds. 1997. Leucocyte Typing VI. Garland Publishing, Inc. London. 2. Dieu, M. 1998. J. Exp. Med. 188:373. 3. Esser, M. et al. 2001. J. Virol. 75:6173. 4. Jeannin, P. et al. 1999. J. Immunol. 162:2044. 5. Kapsogeorgou, E. K. et al. 2001. J. Immunol. 166:3107. 6. Geissmann, F.,et al. 2001. Blood 97:1241. 7. Jakyakumar, A., et al. 2008. Infect Immun. 76:2138. 8. Zaba, LC.,et al. 2007. J Exp Med. 204:3183. 9. Hathcock, K., et al. 1996. Adv. Immunol. 62:131. 10. June, C., et al. 1994. Immunol. Today 15:321.
Additional info: Recognizes human CD86. Species Crossreactivity: chimpanzee, baboon, cynomolgus, rhesus.

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