Home  >  Products  >  CD8a (CD8, Leu2, MAL, p32, T-cell Surface Glycoprotein CD8 alpha Chain, T-lymphocyte Differentiation Antigen T8/Leu-2)
CD8a (CD8, Leu2, MAL, p32, T-cell Surface Glycoprotein CD8 alpha Chain, T-lymphocyte Differentiation Antigen T8/Leu-2)

CD8a (CD8, Leu2, MAL, p32, T-cell Surface Glycoprotein CD8 alpha Chain, T-lymphocyte Differentiation Antigen T8/Leu-2)

Cat no: C2259-98D

Supplier: United States Biological
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CD8a is a 32-34kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the a3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck. Applications: Suitable for use in Flow Cytometry, Costimulation of T Cell Responses and Immunohistochemistry. Other applications not tested. Recommended Dilution: Flow Cytometry: (same/less than)2ug/10e5 cells in 100ul Immunohistochemistry: acetone-fixed, frozen tissue sections Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2259-98D
Reactivities: Human, Mollusc
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG1,k
Purity: Purified by immunoaffinity chromatography.
References: 1. Knapp, W., et al. Eds. 1989. Leucocyte Typing IV. Oxford University Press. New York. 2. Schlossman, S., et al. Eds. 1995. Leucocyte Typing V. Oxford University Press. New York. 3. Mack, C.L., et al. 2004. Pediatr. Res. 56:79. 4. Magidovich, E., et al. 2007. P. Natl. Acad. Sci. USA 104:13022. 5. Thakarl, D., et al. 2008..J. immunol. 180:7431. 5. Kmieciak, M., et al. 2009. J. Transl. Med. 7:89. (FC) 6. Thakral, D., et al. 2008. J. Immunol. 180:7431. (FC) 7. Yoshino, N., et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC) 8. Rout, N., et al. 2010. PLoS One 5:e9787. (FC) 9. Barclay, N., et al. 1993. The Leucocyte Antigen FactsBook. Academic Press Inc. San Diego.
Additional info: Recognizes human CD8. Species Crossreactivity: chimpanzee, baboon, cynomolgus, rhesus, pigtailed macaque.

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