Home  >  Products  >  CD8a (T-cell Surface Glycoprotein CD8 alpha Chain, T-cell Surface Glycoprotein Lyt-2, Lyt-2, Lyt2, CD8 Antigen, alpha Chain, BB154331, Ly-B)
CD8a (T-cell Surface Glycoprotein CD8 alpha Chain, T-cell Surface Glycoprotein Lyt-2, Lyt-2, Lyt2, CD8 Antigen, alpha Chain, BB154331, Ly-B)

CD8a (T-cell Surface Glycoprotein CD8 alpha Chain, T-cell Surface Glycoprotein Lyt-2, Lyt-2, Lyt2, CD8 Antigen, alpha Chain, BB154331, Ly-B)

Cat no: C2259-22F

Supplier: United States Biological
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CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked a and b chains that form the a(CD8a)/b(CD8b) heterodimer and a/a homodimer. CD8a is a 34kD protein that belongs to the immunoglobulin family. The CD8 a/b heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR a/b T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 a/a homodimer is expressed on a subset of g/d TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes, and lymphoid dendritic cells. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck. Applications: Suitable for use in Flow Cytometry, Immunohistochemistry and Immunoprecipitation. Other applications not tested. Recommended Dilution: Flow Cytometry: (same/less than)0.25ug/10e6 cells in 100ul volume Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2259-22F
Reactivities: Mouse
Hosts: Rat
Applications: Flow Cytometry, Immunohistochemistry, Immunoprecipitation
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG2a,k
Purity: Purified by immunoaffinity chromatography.
References: 1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press. 2. Zamoyska R. 1994. Immunity 1:243. 3. Ellmeier W, et al. 1999. Annu. Rev. Immunol. 17:523.
Additional info: Recognizes mouse CD8a.

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