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CD9 (Motility-Related Protein-1) (FITC)

CD9 (Motility-Related Protein-1) (FITC)

Cat no: C2260-05D

Supplier: United States Biological
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CD9, also known as Motility-related protein-1 (MRP-1). CD9 is a 24-27kD transmembrane protein which is a member of the tetraspanin family. It is thought that the main role of tetraspanins is to form signal transducing complexes with integrins at the cell surface, and for this reason CD9 has multiple functions in cell adhesion and motility, platelet activation, gamete fusion and cell proliferation. CD9 has a functional role as a tumor metastatic suppressor and is expressed in melanomas, and colon, lung and breast carcinomas Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry: Neat-1:10, 10ul labels 1x10e6 cells in 100ul. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2260-05D
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry
Size: 100ug
Form: Supplied as a liquid in PBS, pH7.4, 0.09% sodium azide, 1% BSA.
P type: Mab
Isotype: IgG2a
Purity: Purified by Protein G Chromatography.
Alternative names: MRP-1
References: 1. Huang, C.L. et al. (2004) MRP-1/CD9 gene transduction downregulates Wnt signal pathways. Oncogene. 23: 7475-7483. 2. Huang, C.L. et al. (2006) MRP-1/CD9 gene transduction regulates the actin cytoskeleton through the downregulation of WAVE2. Oncogene. 25: 6480-6488. 3. Berditchevski, F. and Odintsova, E. (1999) Characterization of Integrin
Additional info: Recognizes human CD9, also known as Motility-related protein-1 (MRP-1). CD9 is a 24-27kD transmembrane protein which is a member of the tetraspanin family.

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