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CD91, 515kD (LRP, alpha2MR, Low Density Lipoprotein Receptor-related Protein)

CD91, 515kD (LRP, alpha2MR, Low Density Lipoprotein Receptor-related Protein)

Cat no: C2441-95C

Supplier: United States Biological
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Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission. Applications: Suitable for use in Flow Cytometry, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1-5ug/ml (non-reducing conditions) Immunohistochemistry (paraffin, frozen): 1-10ug/ml Flow Cytometry: Recognizes an epitope on the extracellular domain Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2441-95C
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in 0.05M sodium phosphate, 0.15M sodium chloride, pH 7.4. No preservative added.
P type: Mab
Isotype: IgG1,k
Purity: Purified by Protein A affinity chromatography.
References: 1. Strickland, et al., (1990), J. Biol. Chem., 265, 17401-17404 2. Coukos, et al., (1994), Am. J. Pathology, 144, 383-392 3. Rebeck, et al., (1993), Neuron, 11, 575-580. 4. Gonias, et al., (1992), Am. J. Pathology, 141, 37-42 5. Strickland, et al., (1995), FASEB J., 9, 890-898
Additional info: Recognizes the 515kD alpha-chain of human CD91 expressed in certain cell types. A strong immunohistochemical reaction is seen in hepatocytes, tissue macrophages, subsets of neurons and astrocytes in the CNS, fibroblasts, smooth muscle cells and monocyte-derived foam cells in atherosclerotic lesions of arterial walls. Will block a2M binding.

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