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CD91, 515kD (LRP, alpha2MR, Low Density Lipoprotein Receptor-related Protein)

CD91, 515kD (LRP, alpha2MR, Low Density Lipoprotein Receptor-related Protein)

Cat no: C2441-95D

Supplier: United States Biological
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Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission. Applications: Suitable for use in Flow Cytometry, Western Blot, and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2441-95D
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry, Western Blot
Size: 1mg
Form: Supplied as a liquid in 0.05M sodium phosphate, 0.15M sodium chloride, pH 7.4.
P type: Mab
Isotype: IgG1,k
Purity: Purified by Protein A affinity chromatography.
References: 1. Strickland et al. J.Biol.Chem, 265, 17401-17404, 1990; 2. Western blotting, purified human LRP. Coukos et al. American J. Pathology, 144, 383-392, 1994; 3. Histochemical localization of LRP in human placental tissure, and in cultured trophoblasts. Rebeck at el. Neuron, 11, 575-580, 1993; 4. Histochemical localization of LRP in human.
Additional info: Recognizes the human heavy chain 515kD low density lipoprotein receptor-related protein (LRP).

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