CD94 (CD94 Antigen, Killer Cell Lectin-like Receptor Subfamily D Member 1, KLRD1, KLRD1 Protein, Kp43, Natural Killer Cells Antigen CD94, NK Cell Receptor)

Cat no: C2442-09B

Supplier: United States Biological

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CD94 is expressed on the surface of NK cells, NK T cells and some memory phenotype CD8+ cells.2 When CD94 is paired with NKG2A, C, or E subunit, it binds the nonclassical MHC class Ib molecule Qa-1b and results in a CD94high population by flow cytometry.1, 2 Approximately half of NK cells do not express NKG2A, C or E; these cells express CD94 on the surface in a form that does not bind Qa-1b and is believed to be nonfunctional, producing a CD94-low population by flow cytometry.1, 2 CD94 is thought to play a role in the adhesion and activation of the NK cell lineage. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry: 1:50-1:200; 10ul labels 10e6 cells in 100ul Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Catalogue number:	C2442-09B
Reactivities:	Mouse
Hosts:	Rat
Applications:	Flow Cytometry
Size:	100ug
Form:	Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
P type:	Mab
Isotype:	IgG2a
Purity:	Purified by Protein G affinity chromatography.
References:	1. Vance, R.E. et al. (2002) Implications of CD94 deficiency and monoallelic NKG2A expression for natural killer cell development and repertoire function. Proc. Natl. Acad. Sci. USA. 99:868-873, 2. Vance, R.E. et al. (1999) Recognition of the Class Ib Molecule Qa-1b by Putative Activating Receptors CD94/NKG2C and CD94/NKG2E on Mouse Natural Killer Cells. J. Exp. Med. 190:1801-1812.
Additional info:	Recognizes mouse CD94.

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CD94 (CD94 Antigen, Killer Cell Lectin-like Receptor Subfamily D Member 1, KLRD1, KLRD1 Protein, Kp43, Natural Killer Cells Antigen CD94, NK Cell Receptor)

Cat no: C2442-09B

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