Home  >  Products  >  CD96 (CD96 Antigen, DKFZp667E2122, MGC22596, TACTILE, T cell-activated increased late expression protein, T-cell surface protein tactile precursor)
CD96 (CD96 Antigen, DKFZp667E2122, MGC22596, TACTILE, T cell-activated increased late expression protein, T-cell surface protein tactile precursor)

CD96 (CD96 Antigen, DKFZp667E2122, MGC22596, TACTILE, T cell-activated increased late expression protein, T-cell surface protein tactile precursor)

Cat no: C2442-26

Supplier: United States Biological
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CD96 promotes natural killer (NK) cell adhesion to target cells expressing the poliovirus receptor (PVR or CD155). Furthermore CD96 stimulates cytotoxicity of activated NK cells, and mediates acquisition of PVR from target cells. This means NK cells have due to the receptor CD96 a dual receptor system that recognizes nectins and nectin-like molecules on target cells and mediates NK cells adhesion and triggering of effector functions. As PVR is highly expressed in certain tumors, this receptor system may be critical for NK cell recognition of tumors. Applications: Suitable for use in Flow Cytometry and Funcional Studies. Blocks binding of soluble poliovirus receptor (PVR) to NK92 cells. Other applications not tested. Recommended Dilution: Flow Cytometry: 1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2442-26
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry
Size: 100ug
Form: Supplied as a liquid in PBS, 0.1% BSA.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography.
Alternative names: tactile
References: 1. Fuchs, A et al; Cutting edge: CD96 (Tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155). J Immunol 2004, 172: 3994
Additional info: Recognizes CD96, also known as T cell-activated increased late expression (Tactile).

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