Home  >  Products  >  CDC2-related Protein Kinase 7 (Cell Division Cycle 2-related Protein Kinase 7, CRK7, Cdc2-related Kinase Arginine/serine-rich, CRKR, CrkRS, Cell Division Protein Kinase 12, Cyclin-dependent Kinase 12, CDK12, hCDK12, KIAA0904)
CDC2-related Protein Kinase 7 (Cell Division Cycle 2-related Protein Kinase 7, CRK7, Cdc2-related Kinase Arginine/serine-rich, CRKR, CrkRS, Cell Division Protein Kinase 12, Cyclin-dependent Kinase 12, CDK12, hCDK12, KIAA0904)

CDC2-related Protein Kinase 7 (Cell Division Cycle 2-related Protein Kinase 7, CRK7, Cdc2-related Kinase Arginine/serine-rich, CRKR, CrkRS, Cell Division Protein Kinase 12, Cyclin-dependent Kinase 12, CDK12, hCDK12, KIAA0904)

Cat no: C2549-52D

Supplier: United States Biological
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CRK7 is a CDC2/CDK -type protein kinase. Also known as CRKRS, the protein has an arginine/serine-rich (RS) domain that is found predominantly in splicing factors, and extensive proline-rich regions that match the consensus for SH3 and WW domain binding sites. Anti-CrkRS immunoprecipitates have been shown to phosphorylate the C-terminal domain of RNA polymerase II in vitro. CRK7 has been shown to be expressed ubiquitously. Nuclear staining is seen in some carcinomas (breast, lung, others), this may be because these cells are actively dividing and this gene is associated with cell division. ESTs have been isolated from several tissue libraries, including normal lymph and cancerous bone. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin): 6ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human Breast carcinoma Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2549-52D
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.7, 0.01% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: EC=2.7.11.22, EC=2.7.11.23
Additional info: Recognizes human CRK7.

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