Home  >  Products  >  CDC25C, phosphorylated (Ser216) (Cell Division Cycle 25 Homolog C, Cdc 25C, CDC 25, Dual Specificity Phosphatase Cdc25C, M-phase Inducer Phosphatase 3, MPIP3, PPP1R60)

CDC25C, phosphorylated (Ser216) (Cell Division Cycle 25 Homolog C, Cdc 25C, CDC 25, Dual Specificity Phosphatase Cdc25C, M-phase Inducer Phosphatase 3, MPIP3, PPP1R60)

Cat no: C2560-15D


Supplier: United States Biological
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CDC25C is a member of Cdc25 phosphatase family which plays prominent role in the regulation of eukaryotic cell cycle progression. CDC25C activates the mitotic-promoting factor cyclin B1/cdc2 by dephosphorylating T14 and Y15 of cdc2/cyclin B and thus triggers G2/M transition. The protein acts as a converging point of several signal transduction cascades and links the mitotic activation of cdc2/cyclin B to the DNA replication and repair checkpoint. The enzymatic activity of CDC25C is low during interphase and increases sharply at the G2
Catalogue number: C2560-15D
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 50ug
Form: Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: Cell Division Cycle 25C Protein, EC=3.1.3.48, Mitosis Inducer CDC25
References: 1. Sartor, H. et al. Genomics. 13:911-912 (1992). 2. Zwicker, J. et al. Prog. Cell. Cycle. 1:91-99 (1995). 3. Schwindling, SL. et al. Nature. 23:4155-4165 (2004).
Additional info: Recognizes human cdc25C phosphorylated at Ser216.

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