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Cdc6, phosphorylated (Ser106) (CDC18L, HsCDC18, HsCDC6, p62cdc6, Cell Division Cycle 6)

Cdc6, phosphorylated (Ser106) (CDC18L, HsCDC18, HsCDC6, p62cdc6, Cell Division Cycle 6)

Cat no: C2550-06B

Supplier: United States Biological
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The Cdc6 protein is an essential component of pre-replication complexes (preRCs), which assemble at origins of DNA replication during the G1 phase of the cell cycle (1). Cdc6 participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated 2). It has been concluded that expression of Cdc6 is regulated in response to mitogenic signals though transcriptional control mechanisms involving E2F proteins, and that Cdc6 is required for initiation of DNA replication in mammalian cells (3). In vitro, Cdc6 is an excellent substrate for Cdk2, phosphorylated at three sites (Serine 54, Serine 74 and Serine 106) (4). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000-2000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: C2550-06B
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 100ul
Form: Supplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA.
P type: Mab
Isotype: IgG
Purity: Supernatant
References: 1. Hall JR, et al. Mol Biol Cell. 18(9):3340-50, 2007. 2. Williams RS, et al. Proc Natl Acad Sci U S A. 94(1):142-7, 1997. 3. Yan Z, et al. Proc Natl Acad Sci U S A. 95(7):3603-8, 1998 4. Jiang W, et al. Proc Natl Acad Sci U S A. 96(11):6193-8, 1999.
Additional info: Recognizes Cdc6 phosphorylated on Serine 106.

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