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CDK1, phosphorylated (Thr161) (Cell Division Protein Kinase , CDK1, Cyclin-dependent Kinase 1, Cell Division Control Protein 2 Homolog, p34 Protein Kinase)

CDK1, phosphorylated (Thr161) (Cell Division Protein Kinase , CDK1, Cyclin-dependent Kinase 1, Cell Division Control Protein 2 Homolog, p34 Protein Kinase)

Cat no: C2571-07D

Supplier: United States Biological
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Cdc2 is a highly conserved protein serine kinase that plays a key role in regulation of the cell cycle. The ability of cdc2 to exercise control over the cell cycle is dependent upon the phosphorylation of Tyr15 in cdc2. The protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1:S and G2:M phase transitions of eukaryotic cell cycle. Cdc2 during mitosis, signals the inactivation of major anabolic processes such as transcription, mRNA processing, translation, and ribosome biogenesis, thus providing energy needed for the radical and energetically costly structural reorganization of the cell. This is accomplished by phosphorylation and inactivation of several key anabolic elements, including TFIIIB, TFIID, RNA polymerase II, poly(A) polymerase, and translation elongation factor 1. Human Cdc2 gene is usually localized in the chromosomal region 10q21.1. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 Immunohistochemistry (paraffin): 1:50-1:100 Optimal dilutions to be determined by the researcher. Positive Control: COLO205 and K562 cells Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2571-07D
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Jameel S. et al. J. Biol. Chem. 278:16433-16442 (2003).
Additional info: Recognizes human CDC2, phosphorylated at Thr161. Species Crossreactivity: mouse and rat.

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