Cdk4 Antibody

Cat no: 251727

Supplier: ABBIOTEC

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Description
Additional Information

Cyclin-dependent kinase 4 (Cdk4) is the Ser/Thr-kinase component of cyclin D-CDK4 (DC) comple, Xenopus/Amphibian,es that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G1/S transition. Phosphorylation of RB1 by Cdk4 allows dissociation of the transcription factor E2F from the RB/E2F comple, Xenopus/Amphibian,es and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Defects in Cdk4 are a cause of susceptibility to cutaneous malignant melanoma type 3 (CMM3). Malignant melanoma is a malignant neoplasm of melanocytes, arising de novo or from a pre-e, Xenopus/Amphibian,isting benign nevus, which occurs most often in the skin but also may involve other sites.

Catalogue number:	251727
Reactivities:	Human, Mouse, Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	P11802, NP_000066
Antigen:	Recombinant human Cdk4 protein.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 2% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Mouse Monoclonal Antibody
Isotype:	Mouse IgG2a
Clonality:	IML-4
Additional info:	Cell division protein kinase 4; Cyclin-dependent kinase 4; PSK-J3; CDK4