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CDK4 Antibody

CDK4 Antibody

Cat no: 252203

Supplier: ABBIOTEC
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Cyclin-dependent kinase 4 (CDK4) is a Ser/Thr-kinase component of cyclin D-CDK4 (DC) comple, Xenopus/Amphibian,es that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F comple, Xenopus/Amphibian,es and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. CDK4 hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 comple, Xenopus/Amphibian,es are major integrators of various mitogenenic and antimitogenic signals. CDK4 phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. CDK4 is also a component of the ternary comple, Xenopus/Amphibian,, cyclin D/CDK4/CDKN1Bovine, required for nuclear translocation and activity of the cyclin D-CDK4 comple, Xenopus/Amphibian,. Defects in CDK4 are a cause of susceptibility to cutaneous malignant melanoma type 3 (CMM3). Malignant melanoma is a malignant neoplasm of melanocytes, arising de novo or from a pre-e, Xenopus/Amphibian,isting benign nevus, which occurs most often in the skin but also involves other sites.
Catalogue number: 252203
Reactivities: Human, Mouse, Rabbit
Applications: Immunohistochemistry
Size: 0.1 mg
Accession: P11802
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human CDK4.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.5% BSA with 0.09% sodium azide. Antibody was purified by immunogen affinity chromatography.
P type: Rabbit Polyclonal Antibody
Isotype: Rabbit Ig
Additional info: Cell division protein kinase 4; Cyclin-dependent kinase 4; PSK-J3; CDK4
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