CDK4, CT (Cyclin-dependent Kinase 4, Cell Division Protein Kinase 4, CMM3, Cyclin-dependent Kinase 4, PSK-J3)

Cat no: C2574-30B

Supplier: United States Biological

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CDK4, a CDC2/CDK -type protein kinase, regulates cell cycle G1 phase progression. CDK4 associates with and is regulated by D-type cyclins and the CDK inhibitor p16 (CDKN2A). Two alternatively spliced variants have been reported. CDK4 has been shown to phosphorylate the retinoblastoma protein, and mutations in the CDK4 gene have been linked to tumorigenesis in several types of cancers, including cutaneous malignant melanoma. Applications: Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Catalogue number:	C2574-30B
Reactivities:	Mouse
Hosts:	Rabbit
Applications:	Immunohistochemistry, Immunoprecipitation, Western Blot
Size:	50ul
Form:	Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide, 0.2% gelatin.
P type:	Pab
Isotype:	IgG
Purity:	Purified by immunoaffinity chromatography.
Additional info:	Recognizes mouse CDK4. Species sequence homology: Human and rat.

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CDK4, CT (Cyclin-dependent Kinase 4, Cell Division Protein Kinase 4, CMM3, Cyclin-dependent Kinase 4, PSK-J3)

Cat no: C2574-30B

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